There are various scientific research approaches to finding a cure for Limb girdle muscular dystrophies. It is also important to develop adequate natural history studies in parallel. Clinical trials and natural history studies are vital in advancing research to help find a treatment and cure for LGMD.

This is a searchable registry and database of federally supported clinical trial results and private conducted in the United States and around the world.

https://clinicaltrials.gov/

Here you can view all scientific publications on Limb girdle muscular  dystrophies and other diseases.
https://pubmed.ncbi.nlm.nih.gov/

There are three gene therapy studies for sarcoglycanopathies.

LGMD2E OR LGMDR4
- A study has been ongoing since 2011 on LGMD2E or LGMDR4 in the United States, there are two publications on the preclinical phase of prof. Jerry Mendell and Louise Rodino Klapac.

gene therapy

The american project about LGMD2E

The first clinical trial on LGMD2E or LGMDR4 is underway.
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LGMD2D OR LGMDR3
The gene therapy study for LGMD2D or LGMDR3 was developed in the United States and there are 4
scientific publications (2008-2009-2010-2020) by dr. Jerry Mendell.
Read more 

LGMD2C OR LGMDR5
Another study is underway on LGMD2C or LGMDR5 in France, there are two scientific publications by
prof. Isabelle Richard. A clinical trial took place in 2011.
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A study was published in 2012 by prof. Giulio Cossu.

Cell Therapy

A study was published in the United States by Prof. Elizabeth M McNally.

Exon Skipping Therapy

There is an ongoing study for LGMD2i and LGMD2G in the United States.

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CrisprCas9 Therapy

LGMD2E OR LGMDR4

There are two natural history studies for LGMD2E or LGMDR4, one in the United States and one in Milan in Italy.

United States

Milan

LGMD2C-2D-2E OR LGMDR5-R3-R4
There is a natural history study for LGMD2C-2D-2E or LGMDR5-R3-R4 in the United States.

United States

LGMD2E OR LGMDR4

In 2018, the first clinical trial of gene therapy for LGMD2E or LGMDR4 started in the United States.

Gene Delivery Clinical Trial of SRP-9003 for Patients With LGMD2E (Beta-sarcoglycan Deficiency)

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LGMD2D OR LGMDR3

On 2013 a gene therapy clinical trial for LGMD2D or LGMDR3 started in the United States carried out by dr. Jerry Mendell.
Gene Transfer Clinical Trial for LGMD2D (Alpha-sarcoglycan Deficiency) Using scAAVrh74.tMCK.hSGCA
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LGMD2C OR LGMDR5

In 2011, a gene therapy clinical trial was carried out in France for LGMD2C or LGMDR5

Clinical Study of AAV1-gamma-sarcoglycan Gene Therapy for Limb Girdle Muscular Dystrophy Type 2C 

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LGMD2D OR LGMDR3

On 2007, a gene therapy clinical trial was carried out in the United States by Dr. Jerry Mendell

Gene Transfer Therapy for Treating Children and Adults With Limb Girdle Muscular Dystrophy Type 2D (LGMD2D)
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Genethon FR

Sarepta Therapeutics